Antineoplastics – Pharmaco-Logic

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Correctly match the mechanism of action for Carmustine and Cisplatin as an alkylating agent that induces apoptosis:

Deselect Answer

a) Carmustine does inter-strand crosslinking, Cisplatin does inter-strand crosslinking

b) Carmustine does intra-strand crosslinking, Cisplatin does inter-strand crosslinking

c) Carmustine does inter-strand crosslinking, Cisplatin does intra-strand crosslinking

d) Carmustine does intra-strand crosslinking, Cisplatin does intra-strand crosslinking

Which drug mimics uracil to lead to downstream chain termination?

Deselect Answer

a) Cladribine

b) 6-Mercaptopurine

c) Cyclophosphamide

d) 5-Fluorouracil

e) Bleomycin

Which drug mimics adenosine to lead to downstream chain termination?

Deselect Answer

a) Cytarabine

b) 6-Mercaptopurine

c) Cyclophosphamide

d) 5-Fluorouracil

e) Bleomycin

Correctly match the mechanism of action for Vincristine and Paclitaxel that block mitosis:

Deselect Answer

a) Vincristine does inhibition of microtubule polymerization, Paclitaxel does inhibition of microtubule polymerization

b) Vincristine does hyperstabilization of microtubule polymerization, Paclitaxel does inhibition of microtubule polymerization

c) Vincristine does inhibition of microtubule polymerization, Paclitaxel does hyperstabilization of microtubule polymerization

d) Vincristine does hyperstabilization of microtubule polymerization, Paclitaxel does hyperstabilization of microtubule polymerization

Which of the following is the correct mechanism of action for Etoposide?

Deselect Answer

a) Inhibition of DHFR

b) Prevents re-ligation of double stranded DNA breaks

c) Prevents re-ligation of single stranded DNA breaks

d) DNA intercalation

e) Inhibits EGFR

A 59-year old female comes in for breast cancer treatment follow-up. She underwent chemotherapy for 2 months with Doxorubicin. Which of the following side effects is most likely a result from her chemo?

Deselect Answer

a) Pulmonary fibrosis

b) Nephrotoxicity

c) Hepatotoxicity

d) Constrictive cardiomyopathy

e) Dilated cardiomyopathy

f) Ventricular septal defect

g) Bladder fibrosis

h) Acute respiratory distress syndrome

i) Hemolytic uremic syndrome

Which one of the following chemotherapeutic agents inhibits dihydrofolate reductase and is also used at low doses to treat psoriasis?

Deselect Answer

a) Methotrexate

b) Doxorubicin

c) Tamoxifen

d) Cisplatin

A patient is taking chemotherapeutic agents to eliminate CNS tumors and begins to show signs of pulmonary toxicity. The drug most likely responsible for this adverse effect is:

Deselect Answer

a) Methotrexate

b) Paclitaxel

c) Carmustine

d) Sirolimus

e) Doxorubicin

This agent targets the epidermal growth factor receptor (EGFR) to inhibit tumor growth:

Deselect Answer

a) Rituximab

b) Imatinib

c) Tamoxifen

d) Cetuximab

e) Trastuzumab

10.

A patient being with anti-neoplastic agent for colon cancer begins showing signs of hearing loss. What one of the following agents is responsible for this adverse effect?

Deselect Answer

a) 5-Fluorouracil (5-FU)

b) Oxaliplatin

c) Leucovorin (Folinic Acid)

d) Vincristine

e) Doxorubicin

11.

Which one of the following drugs used as an immunosuppressant inhibits T- and B- cell proliferation and causes hyperlipidemia?

Deselect Answer

a) Sirolimus

b) Cyclosporine

c) Mycophenolate mofetil

d) Tacrolimus

e) Methotrexate

12.

A patient comes into the ED with worsening vision. Upon workup, it is discovered she has acute macular degeneration that is positive for vascular endothelial growth factor on biopsy. Which of the following drugs would be the best used to treat this patient’s degeneration?

Deselect Answer

a) Trastuzumab

b) Adalimumab

c) Rituximab

d) Bevacizumab

e) Cetuximab

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